Publications
2024
Erik Jung, Maja Hunter, Andrea Dorst, Alexander Major, Tatjana Teofilovic, Rolf Müller, Karl Gademann
Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis
Helv. Chim. Acta 2024, e202400013
Josep Mas-Roselló, Hermann Tenor, Timea Szabo, Reto Naef, Simon Sieber, Karl Gademann
Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors ̶ Towards Wound Healing
ChemBioChem 2024, e202300801.
2023
Erik Jung, Anastassia Kraimps, Silvia Dittmann, Tizian Griesser, Jordan Costafrolaz, Yves Mattenberger, Simon Jurt, Patrick H Viollier, Peter Sander, Susanne Sievers, Karl Gademann
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species
ChemBioChem 2023, e202300570.
Erik Jung, Karl Gademann
Clinically Approved Antibiotics from 2010 to 2022
CHIMIA, 2023, 77, 230
Tatyana D. Grayfer, Khalil Yamani, Erik Jung, Gleb A. Chesnokov, Isabella Ferrara, Chien-Chi Hsiao, Antri Georgiou, Jeremy Michel, Aurélien Bailly, Simon Sieber, Leo Eberl, Karl Gademann
Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases
JACS Au, 2023, 3, 4, 1151–1161
Tetiana Studer, Daria Morina, Inga S. Shchelik, Karl Gademann
Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol-Sensitive Release Platform
Chem. Eur. J. 2023, 29, e202203913.
Lukas V. Hoff, Simon Schnell, Elie Benchimol, Fabio Pereira Foutinho, Andrea Tomio, Michel Rickhaus, Karl Gademann
Preparation of 3-Bromo-1,2,4,5-tetrazine
Helv. Chim. Acta 2023, e202200198.
2022
Lukas V. Hoff, Joana M. Hauser, Karl Gademann
Cross-Coupling Reactions of 5-Bromo-1,2,3-triazine
J. Org. Chem. 2022, 87, 22, 15684–15692.
Inga S. Shchelik, Karl Gademann
Synthesis and Antimicrobial Evaluation of New Cephalosporin Derivatives Containing Cyclic Disulfide Moieties
ACS Infect. Dis. 2022, 8, 11, 2327–2338.
Lukas V. Hoff, Gleb A. Chesnokov, Anthony Linden, Karl Gademann
Mechanistic Studies and Data Science-Guided Exploration of Bromotetrazine Cross-Coupling
ACS Catal. 2022, 12, 9226–9237.
Mathieu Szponarski and Karl Gademann
Antibody Recognition of Cancer Cells via Glycan Surface Engineering
ChemBioChem 2022, e202200125.
Gleb A. Chesnokov and Karl Gademann
Total syntheses of strained polycyclic terpenes
Chem. Commun. 2022, 58, 4941-4953.
João Vitor Dutra Molino, Roberta Carpine, Karl Gademann, Stephen Mayfield, Simon Sieber
Development of a cell surface display system in Chlamydomonas reinhardtii
Algal Research 2022, 61, 102570.
2021
Inga S. Shchelik, Karl Gademann
Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation
ACS Med. Chem. Lett. 2021, 12, 1898-1904.
Inga S. Shchelik, Joāo V. D. Molino, Karl Gademann
Biohybrid microswimmers against bacterial infections
Acta Biomaterialia 2021, 136, 99–110.
Antri Georgiou, Simon Sieber, Chien-Chi Hsiao, Tatyana Grayfer, Jacob L. Gorenflos, Karl Gademann, Leo Eberl, Aurélien Bailly
Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
Scientific Reports 2021, 11, 22465.
Simon Sieber, Anugraha Mathew, Christian Jenul, Tobias Kohler, Max Bär, Víctor J. Carrión, Francisco M. Cazorla, Urs Stalder, Ya-Chu Hsieh, Laurent Bigler, Leo Eberl, Karl Gademann
Mitigation of Pseudomonas syringae virulence by signal inactivation
Science Advances 2021, 7, eabg2293.
Gleb A. Chesnokov and Karl Gademann
Concise Total Synthesis of Peyssonnoside A
J. Am. Chem. Soc. 2021, 143, 14083–14088.
Simon D. Schnell, Jorge A. González, Jan Sklyaruk, Anthony Linden, Karl Gademann
Boron Trifluoride-Mediated Cycloaddition of 3-Bromotetrazine and Silyl Enol Ethers: Synthesis of 3-Bromo-pyridazines
J. Org. Chem. 2021, 86, 12008–12023.
Lukas V. Hoff, Simon D. Schnell, Andrea Tomio, Anthony Linden, and Karl Gademann
Cross-Coupling Reactions of Monosubstituted Tetrazines
Org. Lett. 2021, 23, 5689–5692.
David Dailler, Andrea Dorst, Daniel Schäfle, Peter Sander, Karl Gademann
Novel fidaxomicin antibiotics through site-selective catalysis
Communications Chemistry 2021, 4, 59.
Simon D Schnell, Mauro Schilling, Jan Sklyaruk, Anthony Linden, Sandra Luber, Karl Gademann
Nucleophilic Attack on Nitrogen in Tetrazines by Silyl-Enol Ethers
Org. Lett. 2021, 23, 2426–2430.
Inga S. Shchelik, Andrea Tomio, Karl Gademann
Design, Synthesis, and Biological Evaluation of Light-Activated Antibiotics
ACS Infect. Dis. 2021, 7, 681–692.
2020
Andrea Dorst, Regina Berg, Christoph G. W. Gertzen, Daniel Schäfle, Katja Zerbe, Myriam Gwerder, Simon D. Schnell, Peter Sander, Holger Gohlke, Karl Gademann
Semisynthetic Analogs of the Antibiotic Fidaxomicin - Design, Synthesis, and Biological Evaluation
ACS Med. Chem. Lett. 2020, 11, 2414–2420.
Andrea Dorst, Inga Shchelik, Daniel Schäfle, Peter Sander, Karl Gademann
Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
Helv. Chim. Acta 2020, 103, e200130
Inga Shchelik, Simon Sieber, Karl Gademann
Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics
Chem. Eur. J. 2020, 26, 16644–16648
Agron Ilazi, Bin Huang, Valery de Almeida Campos, Karl Gademann
Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C-(sp3) Activation
Org. Lett. 2020, 17, 6858–6862
Simon Sieber, Chien-Chi Hsiao, Despina Emmanouilidou, Aleksandra W. Debowski, Keith A. Stubbs, Karl Gademann
Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives
Tetrahedron, 2020, 76, 131386
Pascal Stücheli, Simon Sieber, David W. Fuchs, Leo Scheller, Tobias Strittmatter, Pratik Saxena, Karl Gademann, Martin Fussenegger
Genetically encoded betaxanthin-based small-molecular fluorescent reporter for mammalian cells
Nucleic Acids Res. 2020, 48, e67
Andrea Dorst, Erik Jung, Karl Gademann
Recent Advances in Mode of Action and Biosynthesis Studies of the Clincally Used Antibiotic Fidaxomicin
Chimia 2020, 74, 270–273
Andrea Dorst, Karl Gademann
Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin
Helv. Chim. Acta 2020, 103, e200038
Simon D. Schnell, Lukas V. Hoff, Advaita Panchagnula, Maximilian H. H. Wurzenberger, Thomas M. Klapötke, A. Linden, Simon Sieber, Anthony Linden, Karl Gademann
3-Bromotetrazine: Labelling of Macromolecules via Monosubstituted Bifunctional s-Tetrazines
Chem. Sci. 2020, 11, 3042–3047
Simon Sieber, Simone M. Grendelmeier, Lonnie A. Harris, Douglas A. Mitchell, Karl Gademann
Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabolomic Approach
J. Nat. Prod. 2020, 83, 438–446
Simon Sieber, Christophe Daeppen, Christian Jenul, Vidya Mannancherril, Leo Eberl, Karl Gademann
Biosynthesis and Structure Activity Relationship Investigations of the Diazeniumdiolate Antifungal Agent Fragin
ChemBioChem 2020, 21, 1587–1592
2019
Hiromu Hattori, Lukas V. Hoff, Karl Gademann
Total Synthesis and Structural Revision of Mangrolide D
Org. Lett. 2019, 21, 3456–3459
Raphael Liffert, Nicolas Lardon, Anthony Linden, Karl Gademann
The Furan Shuffling Hypothesis: a Biogenetic Proposal for Eremophilane Sesquiterpenoids
Angew. Chem. Int. Ed. 2019, 58, 7004–7007
Christian Jenul, Simon Sieber, Karl Gademann, Leo Eberl
Ein neues Signalmolekül in Burkholderia cenocepacia
BIOspektrum 2019, 25, 368–371.
Erika A. Crane, Wolfgang Heydenreuter, Katharina R. Beck, Petra Strajhar, Jan Vomacka, Martin Smiesko, Elma Mons, Lydia Barth, Markus Neuburger, Angelo Vedani, Alex Odermatt, Stephan A. Sieber, Karl Gademann
Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases
Bioorg. Med. Chem. 2019, 27, 2508–2520.
Florian Huber, Joel Rösslein, Karl Gademann
Preparation of Indolenines via Nucleophilic Aromatic Substitution
Org. Lett. 2019, 21, 2560–2564
Simon D. Schnell, Anthony Linden, Karl Gademann
Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
Org. Lett. 2019, 21, 4, 1144–1147
Marion Rusch, Arnaud Thevenon, Dominic Hoepfner, Thomas Aust, Christian Studer, Maude Patoor, Patrick Rollin, Madeleine Livendhal, Beatrice Ranieri, Esther Schmitt, Carsten Spanka, Karl Gademann, Laure C. Bouchez
Design and Synthesis of Metabolically Stable t-RNA Synthetase Inhibitors derived from Cladosporin
ChemBioChem 2019, 20, 644–649
Chien-Chi Hsiao, Simon Sieber, Antri Georgiou, Aurélien Bailly, Despina Emmanouilidou, Aurélien Carlier, Leo Eberl, Karl Gademann
Synthesis and Biological Evaluation of the Novel Growth Inhibitor Streptol Glucoside, Isolated from an Obligate Plant Symbiont
Chem. Eur. J. 2019, 25, 1722–1726
Bin Huang, Raphael Liffert, Anthony Linden, Karl Gademann
Metal Free Reagioselective Chloroazidation of Internal Alkynes
Chem. Eur. J. 2019, 24, 981–984
Jan Hanusch, Isabel Kerschgens, Florian Huber, Markus Neuburger, Karl Gademann
Pyrrolizidines for direct air capture and CO2 Conversion
Chem. Comm. 2019, 55, 949–952
2018
Mathieu Szponarski, Fabian Schwizer, Thomas R. Ward, Karl Gademann
On-cell catalysis by surface engineering of live cells with an artificial metalloenzyme
Nature Communications Chemistry 2018, 1, 84
Hiromu Hattori, Joel Roesslein, Patrick Caspers, Katja Zerbe, Hideki Miyatake‐Ondozabal, Daniel Ritz, Georg Rueedi, Karl Gademann
Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A
Angew. Chem. Int. Ed. 2018, 57, 11020–11024
Christian Jenul, Simon Sieber, Christophe Daeppen, Anugraha Mathew, Martina Lardi, Gabriella Pessi, Dominic Hoepfner, Markus Neuburger, Anthony Linden , Karl Gademann, Leo Eberl
Biosynthesis of fragin is controlled by a novel quorum sensing signal
Nature Communications 2018, 9, 1297
Hiromu Hattori, Elias Kaufmann, Hideki Miyatake-Ondozabal, Regina Berg, Karl Gademann
Total Synthesis of Tiacumicin A. Total Synthesis, Relay Synthesis, and Degradation Studies of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)
J. Org. Chem. 2018, 83, 7180–7205
Agron Ilazi, Raphael Liffert, and Karl Gademann
Total Synthesis of the Polyoxygenated Sesquiterpenes Guignarderemophilanes C and D
Helv. Chim. Acta 2018, 101, e1800011
Marta Pinto-Carbó, Karl Gademann, Leo Eberl, Aurelien Carlier
Leaf nodule symbiosis: function and transmission of obligate bacterial endophytes
Current Opinion in Plant Biology 2018, 44, 23–31
Isabel Kerschgens, Karl Gademann,
Antibiotic Algae by Chemical Surface Engineering
ChemBioChem 2018, 19, 439–443
2017
Raphael Liffert, Anthony Linden, Karl Gademann
Total Synthesis of the Sesquiterpenoid Periconianone A Based on a Postulated Biogenesis
J. Am. Chem. Soc. 2017, 139, 16096–16099
Masanori Toyofuku, Gerardo Cárcamo-Oyarce, Tatsuya Yamamoto, Fabian Eisenstein, Chien-Chi Hsiao, Masaharu Kurosawa, Karl Gademann, Martin Pilhofer, Nobuhiko Nomura, Leo Eberl
Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis
Nature Commun. 2017, 8, 481.
Manuel Scherer and Karl Gademann
Total Synthesis and Structural Revision of Aeruginosin KT608A
Org. Lett. 2017, 19, 3915–3918.
Robin Wehlauch and Karl Gademann
Securinega Alkaloids: Complex Structures, Potent Bioactivities, and Efficient Total Syntheses
Asian J. Org. Chem. 2017, 6, 1146–1159.
Andrea Chicca, Regina Berg, Henning J. Jessen, Nicolas Marck, Fabian Schmid, Patrick Burch, Jürg Gertsch, Karl Gademann
Biological Evaluation of Pyridone Alkaloids on the Endocannabinoid System
Bioorg. Med. Chem. 2017, 25, 6102–6114.
Robin Wehlauch, Simone M. Grendelmeier, Hideki Miyatake-Ondozabal, Alexander H. Sandtorv, Manuel Scherer, and Karl Gademann
Investigating Biogenetic Hypotheses of the Securinega Alkaloids: Enantioselective Total Syntheses of Secu’amamine E/ent-Virosine A and Bubbialine
Org. Lett. 2017, 19, 548–551.
Christophe Thommen, Markus Neuburger, and Karl Gademann
Collective Syntheses of Icetexane Natural Products Based on Biogenetic Hypotheses
Chem. Eur. J. 2017, 23, 120–127.
2016
José Gomes, Christophe Daeppen, Raphael Liffert, Joel Roesslein, Elias Kaufmann, Annakaisa Heikinheimo, Markus Neuburger, and Karl Gademann
Formal Total Synthesis of (−)-Jiadifenolide and Synthetic Studies toward seco-Prezizaane-Type Sesquiterpenes
J. Org. Chem. 2016, 81, 11017–11034.
Manuel Scherer, Dominik Bezold, and Karl Gademann
Toxicity of the Aeruginosin Chlorosulfopeptides Investigated by Chemical Synthesis
Angew. Chem. Int. Ed. 2016, 55, 9427–9431.
Suman De Sarkar, Judith F. Blom, Yann Bethuel, Friedrich Jüttner, and Karl Gademann
Allelopathic Activity of the Iron Chelator Anachelin – A Molecular Hybrid with a Dual Mode of Action
Helv. Chim. Acta 2016, 99, 760–773.
Santiago Lascano, Kang-Da Zhang, Robin Wehlauch, Karl Gademann, Naomi Sakai, Stefan Matile
The third orthogonal dynamic covalent bond
Chemical Science 2016, 7, 4720–4724.
Erika A. Crane and Karl Gademann
Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis
Angew. Chem. Int. Ed. 2016, 55, 3882–3902.
Marta Pinto-Carbó, Simon Sieber, Steven Dessein, Thomas Wicker, Brecht Verstraete, Karl Gademann, Leo Eberl and Aurelien Carlier
Evidence of horizontal gene transfer between obligate leaf nodule symbionts
ISME J. 2016, 10, 2092–2105.
Susanne Faltermann, Verena Grundler, Karl Gademann, Jakob Pernthaler, Karl Fent
Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stres
Aquatic Toxicology 2016, 171, 77–87.
2015
Christophe Daeppen, Marcel Kaiser, Markus Neuburger, and Karl Gademann
Preparation of Antimalarial Endoperoxides by a Formal [2 + 2 + 2] Cycloaddition
Org. Lett. 2015, 17, 5420–5423
Isabel P. Kerschgens and Karl Gademann
Direct Preparation of Pyrrolizidines Using Imines and Isonitriles
Synthesis 2015, 47, 3153–3160
Elias Kaufmann, Hiromu Hattori, Hideki Miyatake-Ondozabal, and Karl Gademann
Total Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin
Org. Lett. 2015, 17, 3514–3517
Simon Sieber, Aurélien Carlier, Markus Neuburger, Giselher Grabenweger, Leo Eberl, Karl Gademann
Isolation and Total Synthesis of Kirkamide, an Aminocyclitol from an Obligate Leaf Nodule Symbiont
Angew. Chem. Int. Ed. 2015, 54, 7968–7970. Download the paper postprint
Verena Grundler, Susanne Faltermann, Karl Fent, Karl Gademann
Preparation of Fluorescent Microcystin Derivatives by Direct Arginine Labelling and Their Biological Evaluation
ChemBioChem 2015, 16, 1657–1662.
Karl Gademann
Copy, Edit, and Paste: Natural Product Approaches to Biomaterials and Neuroengineering
Acc. Chem. Res. 2015, 48, 731–739. (open access)
Hideki Miyatake Ondozabal, Elias Kaufmann and Karl Gademann
Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)
Angew. Chem. Int. Ed. 2015, 54, 1933–1936.
Samuel Bader, Michael Lüscher, and Karl Gademann
Synthesis of Maculalactone A and Derivatives for Environmental Fate Tracking Studies
Org. Biomol. Chem. 2015, 13, 199–206.
2014
Verena Grundler, Karl Gademann
Direct Arginine Modification in Native Peptides and Application to Chemical Probe Development
ACS Med. Chem. Lett. 2014, 5, 1290–1295.
Esther Kohler, Verena Grundler, Daniel Häussinger, Rainer Kurmayer, Karl Gademann, Jakob Pernthaler, Judith F. Blom
The toxicity and enzyme activity of a chlorine and sulfate containing aeruginosin isolated from a non-microcystin-producing Planktothrix strain
Harmful Algae 2014, 39, 154–160.
Patrick Burch, Fabian Schmid, Karl Gademann
Neuritogenic Surfaces Using Natural Product Analogs
Advanced Healthcare Materials 2014, 3, 1415–1419.
Fabian Schmid, Maurizio Bernasconi, Henning J. Jessen, Andreas Pfaltz, Karl Gademann
Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin
Synthesis 2014, 864–870.
Cyril Portmann, Simon Sieber, Silvan Wirthensohn, Judith F. Blom, Laeticia Da Silva, Emilie Baudat, Marcel Kaiser, Reto Brun, and Karl Gademann
Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251
J. Nat. Prod. 2014, 77, 557–562.
Patrick Burch, Andrea Chicca, Jürg Gertsch, and Karl Gademann
Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on their Mode of Action
ACS Med. Chem. Lett. 2014, 5, 172–177.
2013
José Gomes, Natalie Huber, Alexander Grunau, Leo Eberl and Karl Gademann
Fluorescent Labeling Agents for Quorum Sensing Receptors (FLAQS) in Live Cells
Chem. Eur. J. 2013, 19, 9766–9770.
Raphael Liffert, Johannes Hoecker, Chandan Kumar Jana, Tom M. Woods, Patrick Burch, Henning Jessen, Markus Neuburger and Karl Gademann
Withanolide A: Synthesis and Structural Requirements for Neurite Outgrowth
Chem. Sci. 2013, 4, 2851–2857.
Christophe Thommen, Chandan Kumar Jana, Markus Neuburger, and Karl Gademann
Syntheses of Taiwaniaquinone F and Taiwaniaquinol A via an Unusual Remote C–H Functionalization
Org. Lett. 2013, 15, 1390–1393.
Johannes Hoecker, Raphael Liffert, Patrick Burch, Robin Wehlauch and Karl Gademann
Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth
Org. Biomol. Chem. 2013, 3314–3321.
Malika Makhlouf Brahmi, Cyril Portmann, Danilo D'Ambrosio, Tom M. Woods, Damiano Banfi, Patrick Reichenbach, Laeticia Da Silva, Emilie Baudat, Gerardo Turcatti, Joachim Lingner and Karl Gademann
Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from Microcystis aeruguinosa PCC 7806
Chem. Eur. J. 2013, 19, 4596–4601.
Hideki Miyatake Ondozabal, Linda Bannwart and Karl Gademann
Enantioselective Total Synthesis of Virosaine A and Bubbialidine
Chemical Communications 2013, 49, 1921–1923
Johannes Hoecker and Karl Gademann
Enantioselective Total Syntheses and Absolute Configuration of JBIR-02 and Mer-A2026B
Org. Lett. 2013, 15, 670–673.
Patrick Burch, Massimo Binaghi, Manuel Scherer, Corinna Wentzel, David Bossert, Luc Eberhardt, Markus Neuburger, Peter Scheiffele and Karl Gademann
Total Synthesis of Gelsemiol
Chem. Eur. J. 2013, 19, 2589–2591.
Fabian Schmid, Henning J. Jessen, Patrick Burch and Karl Gademann
Truncated Militarinone Fragments Identified by Total Chemical Synthesis Induce Neurite Outgrowth
MedChemComm 2013, 4, 135–139
José Gomes, Alexander Grunau, Adrien K. Lawrence, Leo Eberl and Karl Gademann
Bioinspired, Releasable Quorum Sensing Modulators
Chemical Communications 2013, 49, 155–157
José Gomes, Alexander Grunau, Adrien K. Lawrence, Leo Eberl and Karl Gademann
Bioinspired Surfaces Against Bacterial Infections (SCS Fall meeting laureates issue)
Chimia 2013, 67, 275–278
2012
Robin Wehlauch, Johannes Hoecker and Karl Gademann
Nitrocatechols as Tractable Surface Release Systems
ChemPlusChem 2012, 77, 1071–1074. Download the paper postprint
Carles Cantó, Riekelt H. Houtkooper, Eija Pirinen, Dou Y. Youn, Maaike H. Oosterveer, Yana Cen, Pablo J. Fernandez-Marcos, Hiroyasu Yamamoto, Pénélope A. Andreux, Philippe Cettour-Rose, Karl Gademann, Chris Rinsch, Kristina Schoonjans, Anthony A. Sauve, Johan Auwerx
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Cell Metabolism 2012, 15, 838–847.
Elangovan Elamparuthi, Cindy Fellay Markus Neuburger and Karl Gademann
Total Synthesis of Cyrneine A
Angew. Chem. Int. Ed. 2012, 51, 4071–4073.
Jean-Yves Wach and Karl Gademann
Reduce to the Maximum: Truncated Natural Products as Powerful Modulators of Biological Processes
Synlett 2012, 163–170.
2011
Karl Gademann
Controlling Protein Transport by Small Molecules
Current Drug Targets 2011, 12, 1574–1580.
Henning J. Jessen, Andreas Schumacher, Fabian Schmid, Andreas Pfaltz and Karl Gademann
Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C
Org. Lett. 2011, 13, 4368–4370.
Chandan K. Jana, Johannes Hoecker, Tom M. Woods, Henning J. Jessen, Markus Neuburger and Karl Gademann
Synthesis of Withanolide A, Biological Evaluation of its Neuritogenic Properties and Studies on Secretase Inhibition
Angew. Chem. Int. Ed. 2011, 50, 8407–8411.
Henning J. Jessen, Andreas Schumacher, Travis Shaw, Andreas Pfaltz and Karl Gademann
A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
Angew. Chem. Int. Ed. 2011, 50, 4222–4226.
Karl Gademann, Simon Sieber
Chemical Interference of Biological Systems with Natural Products
Chimia 2011, 65, 835–838
Karl Gademann
Out in the Green: Biologically Active Metabolites Produced by Cyanobacteria
Chimia 2011, 65, 416–419.
2010
Henning J. Jessen and Karl Gademann
4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches
Natural Product Reports 2010, 27, 1168–1185.
Hans H. Locher, Daniel Ritz, Philipe Pfaff, Mika Gaertner, Adreja Knezevic, Daniela Sabato, Susanne Schroeder, Damien Barbaras, Karl Gademann
Dimers of Nostocarboline with Potent Antibacterial Activity
Chemotherapy 2010, 56, 318–324.
William Okello, Cyril Portmann, Marcel Erhard, Karl Gademann, Rainer Kurmayer
Occurrence of microcystin-producing cyanobacteria in Ugandan freshwater habitats
Environ. Toxicol. 2010, 25, 367–380.
Chandan Kumar Jana, Rosario Scopelliti, Karl Gademann
A Synthetic Entry into the Taiwaniaquinoids Based on a Biogenetic Hypothesis: Total Synthesis of (-)-Taiwaniaquinone H
Chem. Eur. J. 2010, 16, 7692–7695.
Chandan Kumar Jana, Rosario Scopelliti, Karl Gademann
Connecting C19 Norditerpenoids to C20 Diterpenes: Total Syntheses of 6-Hydroxy-5,6-dehydrosugiol, 6-Hydroxysugiol, and Taiwaniaquinone H, and Formal Synthesis of Dichroanone
Synthesis 2010, 2223–2232.
Karl Gademann, Cyril Portmann, Judith F. Blom, Michael Zeder, Friedrich Jüttner
Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020
J. Nat. Prod. 2010, 74, 980–984.
William Okello, Veronika Ostermayer, Cyril Portmann, Karl Gademann, Rainer Kurmayer
Spatial isolation favours the divergence in microcystin net production by Microcystis in Ugandan freshwater lakes
Water Research 2010, 44, 2803–2814.
Jean-Yves Wach, Stephan Güttinger, Ulrike Kutay, Karl Gademann
The Cytotoxic Styryl Lactone Goniothalamin is an Inhibitor of Nucleocytoplasmic Transport
Bioorg. Med. Chem. Lett. 2010, 20, 2843–2846.
Henning J. Jessen and Karl Gademann
Total Synthesis of the Marine Alkaloid Palau'amine
Angew. Chem. Int. Ed. 2010, 49, 2972–2974.
Barbora Malisova, Samuele Tosatti, Marcus Textor, Karl Gademann, Stefan Zürcher
Poly(ethylene glycol) Adlayers Immobilized to Metal Oxide Substrates Through Catechol Derivatives: Influence of Assembly Conditions on Formation and Stability
Langmuir 2010, 26, 4018–4026.
Simone Bonazzi, Oliv Eidam, Stephan Güttinger, Jean-Yves Wach, Ivo Zemp, Ulrike Kutay, Karl Gademann
Anguinomycins and Derivatives: Total Syntheses, Modeling and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport
J. Am. Chem. Soc. 2010, 132, 1432–1442.
Simone Bonazzi, Damien Barbaras, Luc Patiny, Rosario Scopelliti, Patricia Schneider, Stewart T. Cole, Marcel Kaiser, Reto Brun, Karl Gademann
Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation
Bioorg. Med. Chem. 2010, 18, 1464–1476.
Simone Bonazzi, Massimo Binaghi, Cindy Fellay, Jean-Yves Wach, Karl Gademann
Synthetic Studies on the Sporolides: Exploration of the Enediyne Route
Synthesis 2010, 631–642.
Sina Saxer, Cyril Portmann, Samuele Tosatti, Karl Gademann, Stefan Zürcher, Marcus Textor
Surface Assembly of Catechol-Functionalized Poly(l-lysine)-graft-poly(ethylene glycol) Copolymer on Titanium Exploiting Combined Electrostatically Driven Self-Organization and Biomimetic Strong Adhesion
Macromolecules 2010, 43, 1050–1060.
Sina Saxer, Uwe Pieles, Martin Elsener, Michael Horisberger, Samuele Tosatti, Marcus Textor, Karl Gademann, Stefan Zürcher
Design of a high-throughput device for screening surface modification protocols
Progress in Organic Coatings 2010, 67, 20–27.
2009
Jean-Yves Wach, Karl Gademann
Enantioselective Synthesis of the Sporolide Quinone Acid Fragment
Synlett 2009, 2849–2851.
Henning J. Jessen, Damien Barbaras, Matthias Hamburger, Karl Gademann
Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives
Org. Lett. 2009, 11, 3446–3449.
Karl Gademann, Joanna Kobylinska.
Antimalarial Natural Products of Marine and Freshwater Origin
Chem. Rec. 2009, 9, 187–198.
Karl Gademann, Joanna Kobylinska, Jean-Yves Wach, Tom M. Woods
Surface Modifications Based on the Cyanobacterial Siderophore Anachelin: from Structure to Functional Biomaterials Design
BioMetals 2009, 22, 595–604.
Cyril Portmann, Cora Prestinari, Theresa Myers, Judith Scharte, Karl Gademann
Directed Biosynthesis of Phytotoxic Alkaloids in the Cyanobacterium Nostoc 78-12A
ChemBioChem 2009, 10, 889–895.
Paul G. Becher, Heike I. Baumann, Karl Gademann, Friedrich Jüttner
The Cyanobacterial Alkaloid Nostocarboline: an Inhibitor of Acetylcholinesterase and Trypsin
Journal of Applied Phycology 2009, 21, 103–110.
2008
Cyril Portmann, Judith F. Blom, Marcel Kaiser, Reto Brun, Friedrich Jüttner, Karl Gademann
Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and their Antiparasite Evaluation
J. Nat. Prod. 2008, 71, 1891–1896.
Guntram Christiansen, Wesley Yoshida, Judith F. Blom, Cyril Portmann, Karl Gademann, Thomas Hemscheidt, Rainer Kurmayer
Isolation and Structure Determination of Two Microcystins and Sequence Comparisons of the McyABC Adenylation Domains in Planktothrix species
J. Nat. Prod. 2008, 71, 1881–1886.
Jean-Yves Wach, Barbora Malisova, Simone Bonazzi, Samuele Tosatti, Marcus Textor, Stefan Zürcher, Karl Gademann
Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization
Chem. Eur. J. 2008, 14, 10579–10584.
Damien Barbaras, Karl Gademann
Stable β Turns of Tripeptides in Water through Cation-π Interactions
ChemBioChem 2008, 9, 2398–2401.
Jean-Yves Wach, Simone Bonazzi, Karl Gademann
Antimicrobial Surfaces Through Natural Product Hybrids
Angew. Chem. 2008, 120, 7232-7235; Angew. Chem. Int. Ed. 2008, 47, 7123–7126.
Damien Barbaras, Marcel Kaiser, Reto Brun, Karl Gademann
Potent and Selective Antiplasmodial Activity of the Cyanobacterial Alkaloid Nostocarboline and its Dimers
Bioorg. Med. Chem. Lett. 2008, 18, 4413–4415.
Cyril Portmann, Judith F. Blom, Karl Gademann, Friedrich Jüttner
Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806
J. Nat. Prod. 2008, 71, 1193–1196.
Adrien K. Lawrence and Karl Gademann
Aza-Annulation Strategies in Alkaloid Total Synthesis
Synthesis 2008, 331-351.
Karl Gademann and Cyril Portmann
Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities
Curr. Org. Chem. 2008, 12, 326–341.
2004-2007
Simone Bonazzi, Stephan Güttinger, Ivo Zemp, Ulrike Kutay, Karl Gademann
Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C
Angew. Chem. 2007, 119, 8862-8865; Angew. Chem. Int. Ed. 2007, 46, 8707–8710.
Karl Gademann, Yann Bethuel, Hans H. Locher, Christian Hubschwerlen
Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
J. Org. Chem. 2007, 72, 8361–8370.
Karl Gademann and Simone Bonazzi
Total Synthesis of Complex Cyanobacterial Alkaloids Without Using Protecting Groups
Angew. Chem. 2007, 119, 5754-5756; Angew. Chem. Int. Ed. 2007, 46, 5656–5658.
Karl Gademann
Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling
Chimia 2007, 61, 373–377.
Karl Gademann
Neurobiology of DOPA as a Neurotransmitter
ChemMedChem 2006, 1, 1284.
Karl Gademann
Natural Product Hybrids
Chimia 2006, 60, 841–845.
Stefan Zürcher, David Wäckerlin, Yann Bethuel, Barbora Malisova, Marcus Textor, Samuele Tosatti, Karl Gademann
Biomimetic Surface Modifications Based on the Cyanobacterial Iron Chelator Anachelin
J. Am. Chem. Soc. 2006, 128, 1064–1065.
Judith F. Blom, Tobias Brütsch, Damien Barbaras, Yann Bethuel, Hans H. Locher, Christian Hubschwerlen, Karl Gademann
Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline
Org. Lett. 2006, 8, 737–740.
Yann Bethuel, Karl Gademann
Stereoselective Total Synthesis of (-)-Galantinic Acid
Synlett 2006, 1580–1582.
Karl Gademann
Mechanistic Studies on the Tyrosinase-Catalyzed Formation of the Anachelin Chromophore
ChemBioChem 2005, 6, 913–919.
Yann Bethuel, Karl Gademann
Synthesis and Evaluation of the Bis-Nor-Anachelin Chromophore as Potential Cyanobacterial Ligand
J. Org. Chem. 2005, 70, 6258–6264.
Paul G. Becher, Julien Beuchat, Karl Gademann, Friedrich Jüttner
Nostocarboline: Isolation and Synthesis of a New Cholinesterase Inhibitor from Nostoc 78-12A
J. Nat. Prod. 2005, 68, 1793–1795.
Karl Gademann, H. Budzikiewicz
The peptide alkaloid Anachelin: NMR Spectroscopic Evidence for β-Turn Formation in Aqueous Solution
Chimia 2004, 58, 212–214.
Karl Gademann, Yann Bethuel
A Biomimetic Route to the Peptide Alkaloid Anachelin
Angew. Chem. 2004, 116, 3389-3391; Angew. Chem. Int. Ed. Engl. 2004, 43, 3327–3329.
Karl Gademann, Yann Bethuel
Total Synthesis of Anachelin H
Org. Lett. 2004, 6, 4707–4710.